Elazer edelman biography of mahatma

Elazer R. Edelman, the Edward J. Poitras Professor in Medical Engineering and Science and the director of IMES, also an HST alumnus, lauded the appointment.

Elazer R. Edelman is the Edward J. Graduate work with Robert Langer defined the mathematics of regulated drug delivery systems. His research interests meld medical and scientific training leveraging pathophysiologic insight to improve clinical decision-making and device design. Studies of endothelial and vascular biology led to discovery of the mutable dynamic of endothelial state and importance in regulation of vascular diseases and cancer.

His group reasoned that optimal control of biologic events recapitulated natural regulation. Hence, polymeric controlled drug delivery systems should mimic natural release and vascular implants devised with intimate knowledge of injury they induce. Perivascular and stent-based drug delivery, mechanical organ support and percutaneous heart valves are examples of the former, and therapeutic tissue engineered endothelial cell constructs of the latter.

As Chief Scientific Advisor of Science: Translational Medicine he has set the tone for the national debate on translational research and innovation. For bringing cardiovascular translational research to an international level of excellence the Spanish Parliament and King awarded Edelman the Spanish Order of Civil Merit. Most importantly, Elazer is an avid ice hockey goalie, and with his wife Cheryl parents to comedian-writer Alexander, Olympic athlete AJ, and Austin.

Edelman and his students were among the first to validate the hypothesis that proliferative vascular diseases are the sum of effects from endogenous growth promoters and suppressors. Their characterization of how heparin-like compounds serve as suppressors and heparin-binding growth factors as promoters contributed to the creation of a rigorous framework by which to appreciate how these agents interact with one another in vivo.

Additional studies enabled further definition of the nomenclature and kinetics for the FGF-2 receptor complex, characterization of synergy between many growth factors, and demonstration that the mode of growth factor or inhibitor delivery determines biologic effect. The applied aspects of their work flow from the umbrella of growth modulation.